2020 43(4):852–9.īhanushali D, Anegondi N, Gadde SG, Srinivasan P, Chidambara L, Yadav NK, Sinha Roy A. Predicting 10-year risk of end-organ complications of type 2 diabetes with and without metabolic surgery: a machine learning approach. 2016 57(8):3907–13.Īminian A, Zajichek A, Arterburn DE, Wolski KE, Brethauer SA, Schauer PR, Nissen SE, Kattan MW. Swept-source OCT angiography imaging of the foveal avascular zone and macular capillary network density in diabetic retinopathy. Optical coherence tomography angiographyĪl-Sheikh M, Akil H, Pfau M, Sadda SR.OCTA limitations on projection artifacts, segmentation errors, and data differences between equipment remain to be addressed. Compared to conventional fluorescein angiography, OCTA can be performed more safely in patients with impaired renal function and can provide high-contrast vascular images. Diabetes-induced microvascular changes can be quantified by OCTA, and significant correlations have been shown with serum biomarkers representing pancreatic β-cell function and insulin sensitivity. In proliferative DR, OCTA visualizes detailed features and extent of neovascularization in response to anti-vascular endothelial factor and laser treatment. OCTA of nonproliferative DR shows morphologically well-defined microaneurysms and intraretinal vascular shunts around perfusion dropouts at the deep capillary plexus level. Microvasculature changes, such as foveal avascular zone enlargement and decrease in vascular density of the deep capillary plexus, have been identified in diabetic eyes without clinical retinopathy. Diabetic retinopathy (DR), commonly present in one-third of the patients with diabetes, is a major microvascular complication of diabetes mellitus caused by retinal ischemia and vascular hyperpermeability. Optical coherence tomography angiography (OCTA) visualizes the structure and flow of retinal vasculature using motion contrast.
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